| A-01 Registration at the Conference Venue Tuesday 18:30-21:30 |
| A-02 Opening Ceremony, Welcome Reception Tuesday 18:30-21:30 |
| B-01 Registration at the Conference Wednesday 8:00-8:45 |
| B-02 Welcome and Introduction Wednesday 8:45-9:00 |
| B-03 New Modeling Approaches Wednesday 9:00-10:00 |
| B-04 Nikolaos Alimpertis The estimates for the absorption rate constant in pharmacokinetics and pharmacometrics are wrong: A new era based on the finite absorption time concept rises Wednesday 9:00-9:20 |
| B-05 Robin Chaux Meta-analysis of parameter estimates of non-linear mixed effect models using Approximate Bayesian Computation: application to population pharmacokinetics Wednesday 9:20-9:40 |
| B-06 Mohamed Gewily A Semi Parametric Method for the Estimation of End of Treatment Effect Wednesday 9:40-10:00 |
| B-07 Coffee Break, Software, and Poster Session I Wednesday 10:00-11:30 |
| B-08 Pediatric Extrapolation Wednesday 11:30-12:30 |
| B-09 Kristin Karlsson Paediatric Extrapolation - Opportunities and Challenges Wednesday 11:30-11:50 |
| B-10 Italo Poggesi Extrapolating treatment to children less than 6 years old: the successful story of velmanase alfa in alpha-mannosidosis Wednesday 11:50-12:10 |
| B-11 Bart van Lieshout Population pharmacokinetic analysis of guanabenz in children with Vanishing White Matter: Evaluating scaling adult drug safety and pharmacokinetics data Wednesday 12:10-12:30 |
| B-12 Lunch Wednesday 12:30-14:00 |
| B-13 A tutorial on machine learning & pharmacometrics Wednesday 14:00-14:50 |
| B-14 Nadia Terranova and Uri Nahum Artificial Intelligence and Machine Learning for Next-Generation Model-Informed Precision Medicine: A Tutorial on Practical Applications and Pitfalls Wednesday 14:00-14:50 |
| B-15 Machine Learning in Pharmacometrics Wednesday 14:50-15:30 |
| B-16 Antari Khot Do tree-based machine learning methods outperform Cox regression for progression-free survival prediction in mobocertinib treated lung cancer patients? Wednesday 14:50-15:10 |
| B-17 Ana Victoria Ponce Bobadilla Benefits of integrating machine learning with clinical pharmacology principles for predictive pharmacokinetic modeling Wednesday 15:10-15:30 |
| B-18 RedIF Announcement Wednesday 15:30-15:35 |
| B-19 Coffee Break, Software, and Poster Session II Wednesday 15:35-17:00 |
| B-20 Neurodegenerative diseases Wednesday 17:05-17:45 |
| B-21 Alzahra Hamdan Item Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias Wednesday 17:05-17:25 |
| B-22 Alessio Paris An age-dependent QSP model of Nf trafficking to optimize treatment in neurodegenerative diseases Wednesday 17:25-17:45 |
| C-01 Lewis Sheiner Student Session Thursday 8:30-10:10 |
| C-02 Conor O'Hanlon A framework for drug pharmacokinetics during cardiopulmonary bypass Thursday 8:30-8:55 |
| C-03 Alexander Janssen A generative and causal pharmacokinetic model for haemophilia A: towards an unified model for all factor VIII concentrates. Thursday 8:55-9:20 |
| C-04 Alessandro De Carlo Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat Thursday 9:20-9:45 |
| C-05 Alexandra Lavalley-Morelle Joint modeling of biomarkers dynamics and survival with competing risks to predict the prognostic of patients hospitalized with severe infectious diseases Thursday 9:45-10:10 |
| C-06 Presentation Lewis Sheiner Student Session Awards Thursday 10:10-10:15 |
| C-07 Coffee Break, Software, and Poster Session III Thursday 10:15-11:45 |
| C-08 Modelling Antibody Responses Thursday 11:45-12:25 |
| C-09 Iñaki F. Trocóniz Modeling the dynamics of anti-drug antibodies in cancer patients treated with oncolytic virus in monotherapy or in combination with immune check- point inhibitors Thursday 11:45-12:05 |
| C-10 Quentin Clairon Modeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2 vaccine Thursday 12:05-12:25 |
| C-11 Lunch Thursday 12:25-13:55 |
| C-12 Keynote Lecture Thursday 13:55-14:40 |
| C-13 Alexandra Snyder Current and future applications of circulating tumor DNA (ctDNA) to oncology drug development Thursday 13:55-14:40 |
| C-14 Tumor Growth Dynamics Thursday 14:40-15:20 |
| C-15 Yomna Nassar A joint tumour dynamics and C-reactive protein turnover model to identify early longitudinal prognostic predictors of overall survival in advanced non-small cell lung cancer patients Thursday 14:40-15:00 |
| C-16 Anna Kondic The combined use of propensity score matching and a joint tumor growth dynamics (TGD) - Overall Survival (OS) model to benchmark the efficacy of new treatments for advanced renal cell carcinoma (RCC) Thursday 15:00-15:20 |
| C-17 ACoP Announcement Thursday 15:20-15:25 |
| C-18 Coffee Break, Software, and Poster Session IV Thursday 15:25-16:55 |
| C-19 Stuart Beal Methodology Session Thursday 16:55-17:55 |
| C-20 Freya Bachmann Computing Optimal Drug Dosing with Constraints on Model States in NONMEM Thursday 16:55-17:15 |
| C-21 Dominic Bräm Neural ODE structures based on pharmacokinetic principles Thursday 17:15-17:35 |
| C-22 Zhonghui Huang Development and exploration of exhaustive, stepwise, and heuristic algorithms for automated population pharmacokinetic modelling Thursday 17:35-17:55 |
| C-23 Social Event Thursday 20:30-2:00 |
| D-01 QSP & PBPK Disease Models Friday 9:15-10:15 |
| D-02 Joey Leung Virtual population analysis of a Quantitative Systems Pharmacology (QSP) model of atopic dermatitis (AtD) to evaluate AtD treatments Friday 9:15-9:35 |
| D-03 Natalia Riva Expanding a quantitative systems pharmacology (QSP) modeling framework for acute Hepatitis B to characterize chronic infection Friday 9:35-9:55 |
| D-04 Robin Michelet Development and Application of a Minimal Physiology-based Pharmacokinetics Modelling Framework to Predict Tumor Penetration and Receptor Occupancy. Friday 9:55-10:15 |
| D-05 Preview of PAGE 2024 Friday 10:15-10:20 |
| D-06 Coffee Break Friday 10:20-10:55 |
| D-07 Model Diagnostics Friday 10:55-11:55 |
| D-08 Martin Bergstrand Application relevant shrinkage metrics Friday 10:55-11:15 |
| D-09 Sarah Baklouti Multivariate Exact Discrepancy : a new tool for PK/PD model evaluation Friday 11:15-11:35 |
| D-10 Stefanie Hennig Considerations when deriving time-averaged exposure for censored subjects for logistic regression exposure-response analyses Friday 11:35-11:55 |
| D-11 Closing remarks Friday 11:55-12:05 |
| D-12 Audience Input for potential PAGE 2024 topics Friday 12:05-12:20 |
